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Multiple in-vitro fibroblast studies and a smaller number of clinical-cosmetic studies report improvements in skin elasticity associated with GHK-Cu exposure, linked to increased elastin synthesis and improved lysyl-oxidase-dependent cross-linking

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186 , 187 They have increasingly shown considerable promise as drug delivery systems, and the drug‐loading mode mainly includes endogenous techniques in which the EV‐producing cells also equip vesicles with cargoes (protein, drugs, and modified genes) and exogenous techniques in which cargoes are loaded into EVs after isolation